Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort.
Identifieur interne : 001C21 ( Main/Exploration ); précédent : 001C20; suivant : 001C22Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort.
Auteurs : Mohd H. Abdul-Aziz [Australie] ; Jeffrey Lipman [Australie] ; Murat Akova [Turquie] ; Matteo Bassetti [Italie] ; Jan J. De Waele [Belgique] ; George Dimopoulos [Grèce] ; Joel Dulhunty [Australie] ; Kirsi-Maija Kaukonen [Finlande] ; Despoina Koulenti [Grèce] ; Claude Martin [France] ; Philippe Montravers [France] ; Jordi Rello [Espagne] ; Andrew Rhodes [Royaume-Uni] ; Therese Starr [Australie] ; Steven C. Wallis [Australie] ; Jason A. Roberts [Australie]Source :
- The Journal of antimicrobial chemotherapy [ 1460-2091 ] ; 2016.
Descripteurs français
- KwdFr :
- Acide pénicillanique (administration et posologie), Acide pénicillanique (analogues et dérivés), Acide pénicillanique (pharmacocinétique), Adulte d'âge moyen, Analyse chimique du sang, Antibactériens (administration et posologie), Antibactériens (pharmacocinétique), Femelle, Humains, Maladie grave, Mâle, Perfusions veineuses, Pipéracilline (administration et posologie), Pipéracilline (pharmacocinétique), Résultat thérapeutique, Sujet âgé, Tests de sensibilité microbienne, Thiénamycine (administration et posologie), Thiénamycine (pharmacocinétique), Unités de soins intensifs, Études prospectives.
- MESH :
- administration et posologie : Acide pénicillanique, Antibactériens, Pipéracilline, Thiénamycine.
- analogues et dérivés : Acide pénicillanique.
- pharmacocinétique : Acide pénicillanique, Antibactériens, Pipéracilline, Thiénamycine.
- Adulte d'âge moyen, Analyse chimique du sang, Femelle, Humains, Maladie grave, Mâle, Perfusions veineuses, Résultat thérapeutique, Sujet âgé, Tests de sensibilité microbienne, Unités de soins intensifs, Études prospectives.
English descriptors
- KwdEn :
- Aged, Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (pharmacokinetics), Blood Chemical Analysis, Critical Illness, Female, Humans, Infusions, Intravenous, Intensive Care Units, Male, Microbial Sensitivity Tests, Middle Aged, Penicillanic Acid (administration & dosage), Penicillanic Acid (analogs & derivatives), Penicillanic Acid (pharmacokinetics), Piperacillin (administration & dosage), Piperacillin (pharmacokinetics), Prospective Studies, Thienamycins (administration & dosage), Thienamycins (pharmacokinetics), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Penicillanic Acid, Piperacillin, Thienamycins.
- chemical , analogs & derivatives : Penicillanic Acid.
- chemical , pharmacokinetics : Anti-Bacterial Agents, Penicillanic Acid, Piperacillin, Thienamycins.
- Aged, Blood Chemical Analysis, Critical Illness, Female, Humans, Infusions, Intravenous, Intensive Care Units, Male, Microbial Sensitivity Tests, Middle Aged, Prospective Studies, Treatment Outcome.
Abstract
We utilized the database of the Defining Antibiotic Levels in Intensive care unit patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and clinical outcomes between prolonged-infusion and intermittent-bolus dosing of piperacillin/tazobactam and meropenem in critically ill patients using inclusion criteria similar to those used in previous prospective studies.
DOI: 10.1093/jac/dkv288
PubMed: 26433783
Affiliations:
- Australie, Belgique, Espagne, Finlande, France, Grèce, Italie, Royaume-Uni, Turquie
- Angleterre, Attique (région), Catalogne, Grand Londres, Île-de-France
- Athènes, Barcelone, Londres, Paris
- Université de Londres
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Le document en format XML
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Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name><affiliation wicri:level="3"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Department of Critical Care, Attikon University Hospital, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Department of Critical Care, Attikon University Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name><affiliation wicri:level="3"><nlm:affiliation>Anesthésie réanimation, Hospital Nord, Marseille, France AzuRea Group, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Anesthésie réanimation, Hospital Nord, Marseille, France AzuRea Group, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Montravers, Philippe" sort="Montravers, Philippe" uniqKey="Montravers P" first="Philippe" last="Montravers">Philippe Montravers</name><affiliation wicri:level="3"><nlm:affiliation>Département d'Anesthésie Réanimation, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département d'Anesthésie Réanimation, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="3"><nlm:affiliation>CIBERES, Vall d'Hebron Institut of Research, Universitat Autonoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERES, Vall d'Hebron Institut of Research, Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rhodes, Andrew" sort="Rhodes, Andrew" uniqKey="Rhodes A" first="Andrew" last="Rhodes">Andrew Rhodes</name><affiliation wicri:level="4"><nlm:affiliation>St George's Healthcare NHS Trust and Department of Intensive Care Medicine, St George's University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George's Healthcare NHS Trust and Department of Intensive Care Medicine, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Wallis, Steven C" sort="Wallis, Steven C" uniqKey="Wallis S" first="Steven C" last="Wallis">Steven C. Wallis</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia j.roberts2@uq.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26433783</idno><idno type="pmid">26433783</idno><idno type="doi">10.1093/jac/dkv288</idno><idno type="wicri:Area/PubMed/Corpus">002422</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002422</idno><idno type="wicri:Area/PubMed/Curation">002376</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002376</idno><idno type="wicri:Area/PubMed/Checkpoint">002376</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002376</idno><idno type="wicri:Area/Ncbi/Merge">002B71</idno><idno type="wicri:Area/Ncbi/Curation">002B71</idno><idno type="wicri:Area/Ncbi/Checkpoint">002B71</idno><idno type="wicri:Area/Main/Merge">001C18</idno><idno type="wicri:Area/Main/Curation">001C21</idno><idno type="wicri:Area/Main/Exploration">001C21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort.</title><author><name sortKey="Abdul Aziz, Mohd H" sort="Abdul Aziz, Mohd H" uniqKey="Abdul Aziz M" first="Mohd H" last="Abdul-Aziz">Mohd H. Abdul-Aziz</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Akova, Murat" sort="Akova, Murat" uniqKey="Akova M" first="Murat" last="Akova">Murat Akova</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, School of Medicine, Hacettepe University, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Infectious Diseases, School of Medicine, Hacettepe University, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Division, Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Udine, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Diseases Division, Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Udine</wicri:regionArea><wicri:noRegion>Udine</wicri:noRegion></affiliation></author><author><name sortKey="De Waele, Jan J" sort="De Waele, Jan J" uniqKey="De Waele J" first="Jan J" last="De Waele">Jan J. De Waele</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Critical Care Medicine, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Critical Care, Attikon University Hospital, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Critical Care, Attikon University Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Dulhunty, Joel" sort="Dulhunty, Joel" uniqKey="Dulhunty J" first="Joel" last="Dulhunty">Joel Dulhunty</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Kaukonen, Kirsi Maija" sort="Kaukonen, Kirsi Maija" uniqKey="Kaukonen K" first="Kirsi-Maija" last="Kaukonen">Kirsi-Maija Kaukonen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name><affiliation wicri:level="3"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Department of Critical Care, Attikon University Hospital, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Department of Critical Care, Attikon University Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name><affiliation wicri:level="3"><nlm:affiliation>Anesthésie réanimation, Hospital Nord, Marseille, France AzuRea Group, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Anesthésie réanimation, Hospital Nord, Marseille, France AzuRea Group, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Montravers, Philippe" sort="Montravers, Philippe" uniqKey="Montravers P" first="Philippe" last="Montravers">Philippe Montravers</name><affiliation wicri:level="3"><nlm:affiliation>Département d'Anesthésie Réanimation, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département d'Anesthésie Réanimation, Centre Hospitalier Universitaire Bichat-Claude Bernard, AP-HP, Université Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name><affiliation wicri:level="3"><nlm:affiliation>CIBERES, Vall d'Hebron Institut of Research, Universitat Autonoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERES, Vall d'Hebron Institut of Research, Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rhodes, Andrew" sort="Rhodes, Andrew" uniqKey="Rhodes A" first="Andrew" last="Rhodes">Andrew Rhodes</name><affiliation wicri:level="4"><nlm:affiliation>St George's Healthcare NHS Trust and Department of Intensive Care Medicine, St George's University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George's Healthcare NHS Trust and Department of Intensive Care Medicine, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Wallis, Steven C" sort="Wallis, Steven C" uniqKey="Wallis S" first="Steven C" last="Wallis">Steven C. Wallis</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><affiliation wicri:level="1"><nlm:affiliation>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia j.roberts2@uq.edu.au.</nlm:affiliation><country wicri:rule="url">Australie</country><wicri:regionArea>Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of antimicrobial chemotherapy</title><idno type="eISSN">1460-2091</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Bacterial Agents (pharmacokinetics)</term><term>Blood Chemical Analysis</term><term>Critical Illness</term><term>Female</term><term>Humans</term><term>Infusions, Intravenous</term><term>Intensive Care Units</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Penicillanic Acid (administration & dosage)</term><term>Penicillanic Acid (analogs & derivatives)</term><term>Penicillanic Acid (pharmacokinetics)</term><term>Piperacillin (administration & dosage)</term><term>Piperacillin (pharmacokinetics)</term><term>Prospective Studies</term><term>Thienamycins (administration & dosage)</term><term>Thienamycins (pharmacokinetics)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide pénicillanique (administration et posologie)</term><term>Acide pénicillanique (analogues et dérivés)</term><term>Acide pénicillanique (pharmacocinétique)</term><term>Adulte d'âge moyen</term><term>Analyse chimique du sang</term><term>Antibactériens (administration et posologie)</term><term>Antibactériens (pharmacocinétique)</term><term>Femelle</term><term>Humains</term><term>Maladie grave</term><term>Mâle</term><term>Perfusions veineuses</term><term>Pipéracilline (administration et posologie)</term><term>Pipéracilline (pharmacocinétique)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Tests de sensibilité microbienne</term><term>Thiénamycine (administration et posologie)</term><term>Thiénamycine (pharmacocinétique)</term><term>Unités de soins intensifs</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Penicillanic Acid</term><term>Piperacillin</term><term>Thienamycins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Penicillanic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Penicillanic Acid</term><term>Piperacillin</term><term>Thienamycins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acide pénicillanique</term><term>Antibactériens</term><term>Pipéracilline</term><term>Thiénamycine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide pénicillanique</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Acide pénicillanique</term><term>Antibactériens</term><term>Pipéracilline</term><term>Thiénamycine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Blood Chemical Analysis</term><term>Critical Illness</term><term>Female</term><term>Humans</term><term>Infusions, Intravenous</term><term>Intensive Care Units</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse chimique du sang</term><term>Femelle</term><term>Humains</term><term>Maladie grave</term><term>Mâle</term><term>Perfusions veineuses</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Tests de sensibilité microbienne</term><term>Unités de soins intensifs</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We utilized the database of the Defining Antibiotic Levels in Intensive care unit patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and clinical outcomes between prolonged-infusion and intermittent-bolus dosing of piperacillin/tazobactam and meropenem in critically ill patients using inclusion criteria similar to those used in previous prospective studies.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Royaume-Uni</li><li>Turquie</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Catalogne</li><li>Grand Londres</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Londres</li><li>Paris</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Abdul Aziz, Mohd H" sort="Abdul Aziz, Mohd H" uniqKey="Abdul Aziz M" first="Mohd H" last="Abdul-Aziz">Mohd H. Abdul-Aziz</name></noRegion><name sortKey="Dulhunty, Joel" sort="Dulhunty, Joel" uniqKey="Dulhunty J" first="Joel" last="Dulhunty">Joel Dulhunty</name><name sortKey="Lipman, Jeffrey" sort="Lipman, Jeffrey" uniqKey="Lipman J" first="Jeffrey" last="Lipman">Jeffrey Lipman</name><name sortKey="Roberts, Jason A" sort="Roberts, Jason A" uniqKey="Roberts J" first="Jason A" last="Roberts">Jason A. Roberts</name><name sortKey="Starr, Therese" sort="Starr, Therese" uniqKey="Starr T" first="Therese" last="Starr">Therese Starr</name><name sortKey="Wallis, Steven C" sort="Wallis, Steven C" uniqKey="Wallis S" first="Steven C" last="Wallis">Steven C. Wallis</name></country><country name="Turquie"><noRegion><name sortKey="Akova, Murat" sort="Akova, Murat" uniqKey="Akova M" first="Murat" last="Akova">Murat Akova</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="De Waele, Jan J" sort="De Waele, Jan J" uniqKey="De Waele J" first="Jan J" last="De Waele">Jan J. De Waele</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Dimopoulos, George" sort="Dimopoulos, George" uniqKey="Dimopoulos G" first="George" last="Dimopoulos">George Dimopoulos</name></region><name sortKey="Koulenti, Despoina" sort="Koulenti, Despoina" uniqKey="Koulenti D" first="Despoina" last="Koulenti">Despoina Koulenti</name></country><country name="Finlande"><noRegion><name sortKey="Kaukonen, Kirsi Maija" sort="Kaukonen, Kirsi Maija" uniqKey="Kaukonen K" first="Kirsi-Maija" last="Kaukonen">Kirsi-Maija Kaukonen</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Martin, Claude" sort="Martin, Claude" uniqKey="Martin C" first="Claude" last="Martin">Claude Martin</name></region><name sortKey="Montravers, Philippe" sort="Montravers, Philippe" uniqKey="Montravers P" first="Philippe" last="Montravers">Philippe Montravers</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rhodes, Andrew" sort="Rhodes, Andrew" uniqKey="Rhodes A" first="Andrew" last="Rhodes">Andrew Rhodes</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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